Publications

Protein phosphatase PP2Cα S-glutathionylation regulates cell migration. Kukulage D. S. K., Samarasinghe, K. T. G., Matarage Don, N. N. J., Shivamadhu, M. C., Shishikura, K., Mashhad Ramezani, F., Schiff, W., Padmavathi, R., Matthews, M. L., Ahn, Y. H.* J. Biol. Chem. 2024, In press. Selected as an Editor's Pick & Highlighting the first author.

Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor. Matarage Don, N. N. J., Padmavathi, R., Khasro, T. D., Zaman, M. R. U., Ji, H. F., Ram, J. L., Ahn, Y. H.* ACS Chem. Biol. 2024, link, Highlighting the first author by Journal.

A Homogeneous Time-Resolved Fluorescence Screen to Identify SIRT2 Deacetylase and Defatty-Acylase Inhibitors. Yang, J., Cassel, J., Boyle, B. C., Oppong, D., Ahn, Y. H., Weiser, B. P.* PLOS ONE, 2024, accepted.  

Clickable Glutathione-based Identification of Cysteine Glutathionylation. Matarage Don, N. N. J., Kukulage, D. S. K., Ahn, Y. H.* Curr Protoc. 2023, 10, e907. Link. 

Chemoproteomic Strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration. Kukulage, D. S. K.,# Yapa Abeywardana, M.,# Matarage Don, N. N. J., Hu, R. -H., Shishikura, K., Matthews, M. L., Ahn, Y. H.* Cell Chem. Biol. 2023, # equal contribution. Link. Highlighted in Cell Chem Biol, Link

Chemistry and Biology of Enzymes in Protein Glutathionylation. Oppong, D., Schiff, W., Shivamadhu, M. C., Ahn, Y. H.* Curr. Opin. Chem. Biol. 2023, 75, 102326. Link

Emerging Chemistry and Biology in Protein Glutathionylation. Kukulage, D. S. K., Matarage Don, N. N. J., Ahn, Y. H.* Curr. Opin. Chem. Biol. 2022, 71, 102221. Link

Bach derepression is neuroprotective in mouse model of Parkinson’s disease, Ahuja, M., Kaidery, N. A., Attucks, O. C., McDade, E., Hushpulian, D. M., Gaisin, A., Gaisina, I., Ahn, Y. H., Nikulin, S., Poloznikov, A., Gazaryan, I., Yamamoto, M., Matsumoto, M., Igarashi, K., Sharma, S. M. Thomas, B. Proc. Natl. Acad. Sci. USA. 2021, 118, e2111643118. Link

Identification and Quantification of Glutathionylated Cysteines under Ischemic Stress, Yapa Abeywardana, M., Samarasinghe, K. T. G., Munkanatta Godage, D., Ahn, Y. H. J. Proteome Res. 2021, 20, 4529-4542. Link

Titin N2A Domain and Its Interactions at the Sarcomere, Adewale, A. O., Ahn, Y. H. Int. J. Mol. Sci. 2021, 22, 7563. Link

Synthesis and Evaluation of Tiaprofenic Acid-derived UCHL5 Deubiquitinase Inhibitors, Gurusingha Arachchige, H. S., Herath Mudiyanselage, P. D. H., VanHeck, G. C., Patel, K., Cheaito, H. A., Dou, Q. P., Ahn, Y. H. Bioorg. Med. Chem. 2021, 30, 115931. Link

The isothiocyanate sulforaphane inhibits mTOR in an Nrf2-independent manner, Zhang, Y., Gilmour, A., Ahn, Y. H., de la Vega, L., Dinkova-Kostova, A. T. Phytomedicine 2021, 86, 153062. Link

Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells, Zhang, Y., VanHecke, G. C., Ahn, Y. H., Proby, C. M., Dinkova-Kostova, A. T. Eur. J. Pharmacol. 2020, 889, 173609. Link

Isotopically-labelled Clickable Glutathione to Quantify Protein S-Glutathionylation, VanHecke, G. C.,ª Yapa Abeywardana, M.,ª Huang, B., Ahn, Y. H. ChemBioChem, 2020, 21, 853-859. ªequal contribution. Link. Selected as Very Important Paper by ChemBioChem

Proteomic Identification of Protein Glutathionylation in Cardiomyocytes, VanHecke, G. C., Yapa Abeywardana, M., Ahn, Y. H. J. Proteome Res. 2019, 18, 1806-1818. Link

Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds, Castro, I., Ekinic, E., Huang, X., Cheaito, H. A., Ahn, Y. H., Olivero-Verbel, J., Dou, Q. P. J. Cell. Biochem. 2019, 120, 14065-14075. Link

SMYD2 Glutathionylation Contributes to Degradation of Sarcomeric Proteins. Munkanatta Godage, D. N. P., VanHecke, G. C., Samarasinghe, K. T. G., Feng, H. Z., Hiske, M., Holcomb, J., Yang, Z., Jin, J. -P., Chung, C. S., Ahn, Y. H.  Nature Commun. 2018, 9, 4341. Link

Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition. Patel, K., Ahmed, Z. S. O., Huang, X., Yang, Q., Barzegar, E. E., Neslund-Dudas, C. M., Mitra, B., Elnady, F. A. E. M., Ahn, Y. H., Yang, H., Liu, J., Dou, Q.  Future Med. Chem. 2018, 10, 2087-2108. Link

Redox-inactive peptide disrupting Trx1-Ask1 interaction for selective activation of stress signaling. Kekulandara, D. N., Nagi, S., Seo, H., Chow, C. S., Ahn, Y. H.  Biochemistry 2018, 57, 772–780. Link

Sphingosine-1-phosphate receptor subtype 3 regulates TGF-β-mediated Sani1/E-cadherin pathway and lung adenocarcinoma progression. Zhao, J., Liu, J., Lee, J. F., Zhang, W., VanHecke, G. C., Gartung, A., Gauldie, J., Ahn, Y. H., Lee, M. J.  J. Biol. Chem. 2016, 291, 27343-27353. Link

Clickable glutathione using tetrazine-alkene bioorthogonal chemistry for detecting protein glutathionylation. Kekulandara, D. N., Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Ahn, Y. H. Org. Biomol. Chem. 2016, 14, 10886-10893. Link

Characterization of eicosanoids produced by adipocyte lipolysis: implication of cyclooxygenase-2 in adipose inflammation. Gartung, A., Zhao, J., Chen, S., Mottillo, E., VanHecke, G. C., Ahn, Y. H., Maddipati, K. R., Sorokin, A., Granneman, J., Lee, M.  J. Biol. Chem. 2016, 291, 16001-16010. Link

Identification of protein glutathionylation in response to glucose metabolism. Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., Zhou, Y., Ndombera, F. T., Weerapana, E., Ahn, Y. H. Mol. Biosyst. 2016, 12, 2471-2480. Link

Carbohydrate-based Inducers of Cellular Stress for Targeting Cancer Cells. Ndombera, F. T., VanHecke, G. C., Nagi, S., Ahn, Y. H. Bioorganic. Med. Chem. Lett. 2016, 26, 1452-1456. Link

YcgC Represents a New Protein Deacetylase Family in Prokaryote. Tu, Shun., Guo, S. J., Chen, C. S., Liu, C. X., Jiang, H. W., Ge, F., Deng, J. Y., Zhou, Y. M., Czajkowsky, D., Li, Y., Cole, P. A., Ahn, Y. H., Zhu, H., Tao, S. C.  eLife, 2015, 4, e05322. Link

Synthesizing Clickable Glutathione by Glutathione Synthetase Mutant for Detecting Protein Glutathionylation. Samarasinghe, K. T. G., Ahn, Y. H.  SynLett. 2015, 26, 285-293. Link

A Versatile New Tool to Label Abasic Sites in DNA and Inhibit Base Excision Repair.  Wei, S., Shalhout, S., Ahn, Y. H., Bhagwat, A. S. DNA Repair, 2015, 27, 9-18. Link

Adipocyte Lipolysis-stimulated Interleukin-6 Production Regulates Sphingosine Kinase 1 Activity. Zhang, W., Mottillo, E. P., Zhao, J., Gartung, A., VanHecke, G. C., Lee, J. F., Maddipati, K. R., Xu, H., Ahn, Y. H., Prola, R. L., Granneman, J. G., Lee, M. J.  J. Biol. Chem. 2014, 289, 32178-32185. Link

Metabolic Synthesis of Clickable Glutathione for Chemoselective Detection of Glutathionylation, Samarasinghe, K. T. G., Munkanatta Godage, D. N. P., VanHecke, G. C., Ahn, Y. H.  J. Am. Chem. Soc. 2014, 136, 11566-11569. Link

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. Zhang, Y., Naidu, S. D., Samarasinghe, K., VanHecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. B., Cole, P. A., Ahn, Y. H., Dinkova-Kostova, A. T.  Br. J. Cancer. 2014, 110, 71-82. Link

An Fc Domain Protein-Small Molecule Conjugate as an Enhanced Immunomodulator. Chiang, M. J., Hobert, M. A., Kalin, J. H., Ahn, Y. H., Giddens, J., Amin, M. N., Taylor, M. S., Collins, S. L., Chan-Li, Y., Waickman, A., Hsiao, P. Y., Bolduc, D., Leahy, D. J., Horton, M. R., Wang, L. X., Powell, J. D., Cole, P. A. J. Am. Chem. Soc. 2014, 136, 3370-3373. Link

Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Dancy, B. M., Crump, N. T., Peterson, D. J., Mukherjee, C., Bowers, E. M., Ahn, Y. H., Yoshida, M., Zhang, J., Mahadevan, L. C., Meyers, D. J., Boeke, J. D., Cole, P. A. Chembiochem. 2012, 13, 2113-2121. Link

HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Zhang, Y., Ahn, Y. H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A., Dinkova-Kostova, A. T.  Chem. Biol. 2011, 18, 1355-1361. Link

Development of Neh2-Luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Smirnova, N. A., Haskew-Layton, R. E., Manuela, B., Hushpulian, D. M., Payappilly, J. B., Speer, R. E., Ahn, Y. H., Rakhman, I., Cole, P. A., Pinto, J. T., Ratan, R. R., Gazaryan, I. G. Chem. Biol. 2011, 18, 752-765. Link

Hyaluronan Fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor. Am. J. Respir. Collins, S. L., Black, K. E., Chan-Li, Y., Ahn, Y. H., Cole, P. A., Powell, J. D., Horton, M. R. Cell. Mol. Biol. 2011, 45, 675-683. Link

Bodipy-diacrylate imaging probes for targeted proteins inside live cells. Lee, J. J., Lee, S. C., Zhai, D., Ahn, Y. H., Yeo, H. Y., Tan, Y. L., Chang, Y. T.  Chem. Commun. 2011, 47, 4508-4510. Link

The binding of fluorophores to proteins depends on the cellular environment. Kim, Y. K., Lee, J. S., Bi. X., Ha, H. H., Ng, S. H., Ahn, Y. H., Lee, J. J., Wagner, B. K., Clemons, P. A., Chang, Y. T. Angew. Chem. Int. Ed. Engl. 2011, 50, 2761-2763. Link

Electrophilic tuning of the chemoprotective natural product sulforaphane. Ahn, Y. H., Hwang, Y., Liu, H.; Wang, X. J., Zhang, Y., Stephenson, K. K., Boronina, T. N., Cole, R. N., Dinkova-Kostova, A. T., Talalay, P., Cole, P. A. Proc. Natl. Acad. Soc. USA. 2010, 107, 9590-9595. Link

A fluorescent rosamine compound selectively stains pluripotent stem cells. Im, C. N., Kang, N. Y., Ha, H. H., Bi, X., Lee, J. J., Park, S. J., Lee, S. Y., Vendrell, M., Kim, Y. K., Lee, J. S., Li, J., Ahn, Y. H., Feng, B., Ng, H. H., Yun, S. W., Chang, Y. T. Angew. Chem. Intl. Ed. Engl. 2010, 49, 7497-7500. Link

Combinatorial synthesis of a triphenylmethine library and their application in the development of surface enhanced Raman scattering (SERS) probes. Cho, S. J., Ahn, Y. H., Maiti, K. K., Dinish, U. S., Fu, C. Y., Thoniyot, P., Olivo, M., Chang, Y. T. Chem. Commun. 2010, 46, 722-724. Link

Control of muscle differentiation by a mitochondria-targeted fluorophore. Kim, Y. K., Ha, H. H., Lee, J. S., Bi, X., Ahn, Y. H., Hajar, S., Lee, J. J., Chang, Y. T. J. Am. Chem. Soc. 2010, 132, 576-579. Link

Selective human serum albumin sensor from the screening of a fluorescent rosamine library. Ahn, Y. H., Lee, J. S., Chang, Y. T. J. Combi. Chem. 2008, 10, 376-380. Link

Small molecule fluorophores to detect cell-state switching in the context of high-throughput screening. Wagner, B. K., Carrinski, H., Ahn, Y. H., Kim, Y. K., Gilbert, T. J., Fomina, D., Schreiber, S. L., Chang, Y. T., Clemons, P. A. J. Am. Chem. Soc. 2008, 130, 4208-4209. Link

Styryl-based potential in vivo imaging agents for beta-amyloid plaques. Li, Q., Min, J., Ahn, Y. H., Namm, J., Kim, E. M., Lui, R., Ji, Y., Wu, Z. H., Wisniewski, T., Chang, Y. T. Chembiochem 2007, 8, 1679-1687. Link

Combinatorial synthesis of dapoxyl dyes and application to site-selective probe for human serum albumin. Min, J., Lee, J. W., Ahn, Y. H., Chang, Y. T. J. Combi. Chem. 2007, 9, 1079-1083. Link

Tagged small molecule library approach for facilitated chemical genetics. Ahn, Y. H., Chang, Y. T. Acc. Chem. Res. 2007, 40, 1025-1033. Link

Combinatorial rosamine library and application to in vivo glutathione probe. Ahn, Y. H., Lee, J. S., Chang, Y. T. J. Am. Chem. Soc. 2007, 129, 4510-4511. Link

RNA-selective, live cell imaging probes for studying nuclear structure and function. Li, Q., Kim, Y. K., Namm, J., Kulkarni, A., Rosania, G., Ahn, Y. H., Chang, Y. T. Chem. Biol. 2006, 13, 615-623. Link

Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. Chi, Y., Zhou, B., Wang, W. Q., Chung, S. K., Kwon, Y. U., Ahn, Y. H., Chang, Y. T., Tsujishita, Y., Hurley, J. H., Zhang, Z. Y.  J. Biol. Chem. 2004, 279, 44987-44995. Link

Molecular evolution using intramolecular acyl migration on myo-inositol benzoates with thermodynamic and kinetic selectors. Ahn, Y. H., Chang, Y. T. Chem. Eur. J. 2004, 10, 3543-3547. Link

Molecular evolution on chiro-inositol dibenzoate using intramolecular acyl migration and selection by phenyl boronic acid. Ahn, Y. H., Chang, Y. T.  J. Combi. Chem. 2004, 6, 293-296. Link

A study on the effect of lanthanide ion coordination on the stereoselective synthesis of β-mannopyranosides. Ahn, Y. H., Chung, S. K. Kor. Chem. Soc. 2003, 24, 116-118. Link

A study of benzene 1,2,4-trisphosphate derivatives as inositol 1,4,5-trisphosphate 3-kinase inhibitors. Ahn, Y. H., Chung, S. K.  Kor. Chem. Soc. 2002, 23, 515-517. Link

A novel DAST-induced debenzylative cycloetherization in D-1,2-O-isopropylidene-3,4,5-tri-O-benzyl-myo-inositol. Chung, S. K., Kwon, Y. U., Ahn, Y. H., Jeong, T. H., Chang, Y. T.  Kor. Chem. Soc. 2000, 21, 274-276. Link